ABSTRACT
Background:To assess the occurrence of risk factors in patients with STEMI with special reference to Thyroid functions and Thyroid profile (Hypothyroidism/ Hyperthyroidism). Methods: A total of 140 patients diagnosed with ST segment elevation myocardial infarction (STEMI) admitted to ICU/CCU of NIMS Medical College & Hospital over the period of 18 months (june 2016 - november 2017) will be included in the study and subsequently evaluated for presence of risk factors and thyroid dysfunction. Majority of subjects belonged to rural areas located near to the hospital of either sex above the age of 18 years. On the basis of history, clinical examination, inclusion and exclusion criteria of the study, subjects were selected. It is an observational cross- sectional study. Statistical analysis were done using Fisher test, student ‘t’ test and Chi-Square test. ‘p’ value less than 0.05 is taken as significant. Results: Out of 140 patients with STEMI, 20 patients had thyroid dysfunction while 120 patients had euthyroid status. Subclinical hypothyroidism were reported in 12 (8.6%) patients while Hypothyroidism were noticed in 4 (2.9%) patients. Subclinical hyperthyroidism and Hyperthyroidism were observed in 3 (2.1%) and 1( 0.7%) patients, respectively. Out of 140 patients with STEMI, 2 patients with euthyroid status died while 8 patients with thyroid dysfunction died with p=0.001 which was statistically significant Conclusion: Thyroid dysfunction significantly increases relative risk of mortality as compared to euthyroid function in patients with STEMI.
ABSTRACT
Background: Analysis of TIMI risk score & correlation with ST elevation myocardial infarction (STEMI). Methods: This is a 12 months Observational Cross- sectional study conducted at NIMS Medical College and Hospital- a tertiary hospital in rural areas close to Jaipur. In this study we included 60 patients with acute myocardial infarction who were admitted to the coronary care unit of NIMS HOSPITAL JAIPUR during the year JAN 2015 –DEC 2015. The data obtained were analysed using Excel sheet/SPSS software. Tests of significance were done using the Chi - square test at 95% confidence interval. Results: According to our study myocardial infarction was more common in male compared to female (male:female ratio 4:1) Complications rate is significantly higher in male patients(p=0.0010) compared to female patients(p=0.0114). Mortality is increased with the increase in TIMI risk score. Conclusion: TIMI Risk score for ST segment Elevation Myocardial Infarction (STEMI) may be readily applied at the bedside at the time of hospital presentation and captures the majority of prognostic information offered by a full logistic regression model. The mortality increased proportionally with TIMI score. This risk assessment tool is likely to be clinically useful in the triage and management of patients eligible for fibrinolytic therapy and may also serve as a valuable aid in clinical research. Sufficiently simple to be practical at the bedside and effective for risk assessment across a heterogeneous spectrum of patients, the TIMI risk score may be clinically useful in the triage and treatment of patients with STEMI who undergo acute reperfusion therapy.
ABSTRACT
Background: Diabetic retinopathy is one of the leading causes of blindness in the world. Hypomagnesaemia has been reported to occur at an increased frequency among patients with type 2 diabetes mellitus (DM) with retinopathy compared with their counterparts without diabetic retinopathy. The study was done with aimed whether there is any correlation between serum magnesium concentration and diabetic retinopathy in a rural population. Aim: This study was carried out to find the correlation between serum magnesium levels in diabetic patients with retinopathy. Methods: 100 type 2 DM patients admitted in NIMS Medical Collage Hospital, Jaipur over the period of 8 months between 1st December 2014 to 31th July 2015, were selected for this study. Detailed history, general physical examination, systemic examination, and various investigations like fasting blood sugar (FBS), post prandial blood sugar after 2 hrs (PP2BS), glycosylated hemoglobin (HbA1C), Blood urea, serum creatinine and urine examination were carried out. Serum magnesium was estimated by Calmagite dye method. Retinopathy was assessed by direct opthalmoscopy. Results: Prevalence of hypomagnesaemia in type 2 diabetic was 30% hypomagnesaemia was significantly higher in diabetic with retinopathy compared to diabetic without retinopathy. Serum magnesium level is in uncontrolled DM when compare with control DM. No significant associations existed between serum magnesium concentrations and other factors like age, sex, durations of diabetes, mode of treatment. Conclusion: Prevalence of hypomagnesaemia in type 2 diabetics is 30%, And especially more significant in diabetes with retinopathy when comparison to diabetes without retinopathy.